Channelopathy-causing mutations in the S45A/S45B and HA/HB helices of KCa2.3 and KCa3.1 channels alter their apparent Ca2+ sensitivity.

Orfali, Razan; Nam, Young-Woo; Nguyen, Hai Minh; Rahman, Mohammad Asikur; Yang, Grace; Cui, Meng; Wulff, Heike; Zhang, Miao

Channelopathy-causing mutations in the S₄₅A/S₄₅B and HA/HB helices of K_Ca2.3 and K_Ca3.1 channels alter their apparent Ca²⁺ sensitivity.

Orfali, Razan; Nam, Young-Woo; Nguyen, Hai Minh; Rahman, Mohammad Asikur; Yang, Grace; Cui, Meng; Wulff, Heike; Zhang, Miao.

Afiliación

Orfali R; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States of America.
Nam YW; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States of America.
Nguyen HM; Department of Pharmacology, University of California Davis, Davis, California 95616, United States of America.
Rahman MA; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States of America.
Yang G; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States of America.
Cui M; Department of Pharmaceutical Sciences, Northeastern University School of Pharmacy, Boston, Massachusetts 02115, United States of America.
Wulff H; Department of Pharmacology, University of California Davis, Davis, California 95616, United States of America.
Zhang M; Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, California 92618, United States of America. Electronic address: zhang@chapman.edu.

Cell Calcium ; 102: 102538, 2022 03.

Article en En | MEDLINE | ID: mdl-35030515

Asunto(s)

Canalopatías; Canales de Potasio de Conductancia Intermedia Activados por el Calcio; Humanos; Canales de Potasio de Conductancia Intermedia Activados por el Calcio/genética; Mutación/genética; Canales de Potasio de Pequeña Conductancia Activados por el Calcio/genética

Palabras clave

HA/HB helices; K(Ca)2.3 and K(Ca)3.1 channels; Negative gating modulator; S(45)A/S(45)B (helices)

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Canales de Potasio de Conductancia Intermedia Activados por el Calcio / Canalopatías Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cell Calcium Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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