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Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity.
Dólleman, Sophie C; Agten, Stijn M; Spronk, Henri M H; Hackeng, Tilman M; Bos, Mettine H A; Versteeg, Henri H; van Zonneveld, Anton Jan; de Boer, Hetty C.
Afiliación
  • Dólleman SC; Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, the Netherlands.
  • Agten SM; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
  • Spronk HMH; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
  • Hackeng TM; Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands.
  • Bos MHA; Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
  • Versteeg HH; Division of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
  • van Zonneveld AJ; Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, the Netherlands.
  • de Boer HC; Department of Internal Medicine (Nephrology), Einthoven Laboratory for Vascular and Regenerative Medicine, Leiden, the Netherlands.
J Thromb Haemost ; 20(4): 996-1007, 2022 04.
Article en En | MEDLINE | ID: mdl-35037739
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fibrilación Atrial / Dabigatrán Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Fibrilación Atrial / Dabigatrán Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Thromb Haemost Asunto de la revista: HEMATOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos