Single-dose of LC51-0255, a selective S1P<sub>1</sub> receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans.

Won Lee, Sang; Hwang, Inyoung; Oh, Jaeseong; Lee, SeungHwan; Jang, In-Jin; Yu, Kyung-Sang

Single-dose of LC51-0255, a selective S1P₁ receptor modulator, showed dose-dependent and reversible reduction of absolute lymphocyte count in humans.

Won Lee, Sang; Hwang, Inyoung; Oh, Jaeseong; Lee, SeungHwan; Jang, In-Jin; Yu, Kyung-Sang.

Afiliación

Won Lee S; Department of Clinical Pharmacology and Therapeutics, Hanyang University Seoul Hospital, Seoul, South Korea.
Hwang I; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Oh J; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Lee S; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Jang IJ; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.
Yu KS; Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, South Korea.

Clin Transl Sci ; 15(4): 1074-1083, 2022 04.

Article en En | MEDLINE | ID: mdl-35045208

Asunto(s)

Relación Dosis-Respuesta a Droga; Administración Oral; Método Doble Ciego; Semivida; Voluntarios Sanos; Humanos; Recuento de Linfocitos

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Relación Dosis-Respuesta a Droga Tipo de estudio: Clinical_trials Límite: Humans Idioma: En Revista: Clin Transl Sci Año: 2022 Tipo del documento: Article País de afiliación: Corea del Sur

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