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Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses.
Balachandran, Harikrishnan; Phetsouphanh, Chansavath; Agapiou, David; Adhikari, Anurag; Rodrigo, Chaturaka; Hammoud, Mohamed; Shrestha, Lok Bahadur; Keoshkerian, Elizabeth; Gupta, Money; Turville, Stuart; Christ, Daniel; King, Cecile; Sasson, Sarah C; Bartlett, Adam; Grubor-Bauk, Branka; Rawlinson, William; Aggarwal, Anupriya; Stella, Alberto Ospina; Klemm, Vera; Mina, Michael M; Post, Jeffrey J; Hudson, Bernard; Gilroy, Nicky; Konecny, Pam; Ahlenstiel, Golo; Dwyer, Dominic E; Sorrell, Tania C; Kelleher, Anthony; Tedla, Nicodemus; Lloyd, Andrew R; Martinello, Marianne; Bull, Rowena A.
Afiliación
  • Balachandran H; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Phetsouphanh C; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Agapiou D; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Adhikari A; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia; Department of Infection and Immunology, Kathmandu Research Institute for Biological Sciences, Lalitpur, Nepal.
  • Rodrigo C; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Hammoud M; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Shrestha LB; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Keoshkerian E; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Gupta M; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Turville S; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Christ D; Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • King C; Garvan Institute of Medical Research, Sydney, NSW, Australia.
  • Sasson SC; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Bartlett A; The Kirby Institute, UNSW, Sydney, NSW, Australia; Sydney Children's Hospital Randwick, Randwick, NSW, Australia.
  • Grubor-Bauk B; Viral Immunology Group, The University of Adelaide & Basil Hetzel Institute for Translational Health Research, Adelaide, SA, Australia.
  • Rawlinson W; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; Serology and Virology Division, Department of Microbiology, New South Wales Health Pathology, Randwick, Sydney, NSW, Australia.
  • Aggarwal A; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Stella AO; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Klemm V; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Mina MM; Northern Beaches Hospital, Frenchs Forest, NSW, Australia.
  • Post JJ; Prince of Wales Hospital, Sydney, NSW, Australia; Prince of Wales Clinical School, UNSW, Sydney, NSW, Australia.
  • Hudson B; Royal North Shore Hospital, Sydney, NSW, Australia.
  • Gilroy N; Westmead Hospital, Sydney, NSW, Australia.
  • Konecny P; St George Hospital, Sydney, NSW, Australia.
  • Ahlenstiel G; Blacktown Mt Druitt Hospital, Blacktown, NSW, Australia; Blacktown Clinical School, School of Medicine, Western Sydney University, Mount Druitt, NSW, Australia.
  • Dwyer DE; New South Wales Health Pathology - Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, NSW, Australia.
  • Sorrell TC; University of Sydney Institute for Infectious Diseases and Faculty of Medicine and Health, Westmead, NSW, Australia.
  • Kelleher A; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Tedla N; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia.
  • Lloyd AR; The Kirby Institute, UNSW, Sydney, NSW, Australia.
  • Martinello M; The Kirby Institute, UNSW, Sydney, NSW, Australia; Prince of Wales Hospital, Sydney, NSW, Australia.
  • Bull RA; School of Medical Sciences, Faculty of Medicine, UNSW, Sydney, NSW, Australia; The Kirby Institute, UNSW, Sydney, NSW, Australia. Electronic address: r.bull@unsw.edu.au.
Cell Rep ; 38(6): 110345, 2022 02 08.
Article en En | MEDLINE | ID: mdl-35090598
Understanding the long-term maintenance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunity is critical for predicting protection against reinfection. In an age- and gender-matched cohort of 24 participants, the association of disease severity and early immune responses on the maintenance of humoral immunity 12 months post-infection is examined. All severely affected participants maintain a stable subset of SARS-CoV-2 receptor-binding domain (RBD)-specific memory B cells (MBCs) and good neutralizing antibody breadth against the majority of the variants of concern, including the Delta variant. Modeling these immune responses against vaccine efficacy data indicate a 45%-76% protection against symptomatic infection (variant dependent). Overall, these findings indicate durable humoral responses in most participants after infection, reasonable protection against reinfection, and implicate baseline antigen-specific CD4+ T cell responses as a predictor of maintenance of antibody neutralization breadth and RBD-specific MBC levels at 12 months post-infection.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos ampliamente neutralizantes / SARS-CoV-2 / Células B de Memoria Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article País de afiliación: Australia
Texto completo
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos ampliamente neutralizantes / SARS-CoV-2 / Células B de Memoria Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male País/Región como asunto: Oceania Idioma: En Revista: Cell Rep Año: 2022 Tipo del documento: Article País de afiliación: Australia