Zebrafish and idiopathic scoliosis: the 'unknown knowns'.

Liu, Ziyang; Hai, Yong; Li, Zhuoran; Wu, Lingyun

Liu, Ziyang; Hai, Yong; Li, Zhuoran; Wu, Lingyun.

Afiliación

Liu Z; Department of Orthopedics, Capital Medical University, Beijing, China; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: altanliu@gmail.com.
Hai Y; Department of Orthopedics, Capital Medical University, Beijing, China; Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China. Electronic address: yong.hai@ccmu.edu.cn.
Li Z; Department of Neurology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Wu L; Karolinska Institutet, Stockholm, Sweden.

Trends Genet ; 38(6): 524-528, 2022 06.

Article en En | MEDLINE | ID: mdl-35115176

ABSTRACT

ABSTRACT

The etiology and heterogeneity of idiopathic scoliosis (IS) are poorly understood. Studies using scoliotic zebrafish models have indicated a potential link between ciliary defects and scoliosis. They may further explain the onset of IS partially. However, it is necessary to further interpret the link between this progress and clinical medicine.

Asunto(s)

Escoliosis; Pez Cebra; Animales; Modelos Animales de Enfermedad; Escoliosis/genética; Columna Vertebral; Pez Cebra/genética; Proteínas de Pez Cebra

Palabras clave

ciliopathy; gene sequencing; heterogeneity; idiopathic scoliosis; motile cilia; zebrafish

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Escoliosis / Pez Cebra Límite: Animals Idioma: En Revista: Trends Genet Asunto de la revista: GENETICA Año: 2022 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google