Amylin-Calcitonin receptor signaling in the medial preoptic area mediates affiliative social behaviors in female mice.
Nat Commun
; 13(1): 709, 2022 02 08.
Article
en En
| MEDLINE
| ID: mdl-35136064
ABSTRACT
Social animals actively engage in contact with conspecifics and experience stress upon isolation. However, the neural mechanisms coordinating the sensing and seeking of social contacts are unclear. Here we report that amylin-calcitonin receptor (Calcr) signaling in the medial preoptic area (MPOA) mediates affiliative social contacts among adult female mice. Isolation of females from free social interactions first induces active contact-seeking, then depressive-like behavior, concurrent with a loss of Amylin mRNA expression in the MPOA. Reunion with peers induces physical contacts, activates both amylin- and Calcr-expressing neurons, and leads to a recovery of Amylin mRNA expression. Chemogenetic activation of amylin neurons increases and molecular knockdown of either amylin or Calcr attenuates contact-seeking behavior, respectively. Our data provide evidence in support of a previously postulated origin of social affiliation in mammals.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Área Preóptica
/
Conducta Social
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Conducta Animal
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Receptores de Calcitonina
/
Receptores de Polipéptido Amiloide de Islotes Pancreáticos
Límite:
Animals
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón