Obsessive-compulsive disorder and the associated risk of autoimmune skin diseases: a nationwide population-based cohort study.
CNS Spectr
; : 1-7, 2022 Feb 11.
Article
en En
| MEDLINE
| ID: mdl-35147076
ABSTRACT
BACKGROUND:
The concurrent incidence of autoimmune comorbidities in obsessive-compulsive disorder (OCD) is known. However, the association between OCD and related autoimmune skin diseases (ASDs) has not been well studied.OBJECTIVE:
This study aimed to investigate the association between OCD and the risk of ASDs.METHODS:
To assess the risk of developing ASDs, we recruited 44 324 patients with OCD and 177 296 matched controls from the National Health Insurance Research Database in Taiwan. A Cox regression model was used for the analyses.RESULTS:
After adjusting for confounders, an increased risk of ASDs among the patients with OCD (adjusted hazard ratio [aHR] 6.36; 95% confidence interval [CI] 5.43-7.45) was found when compared to the controls. Statistically significant associations were found between OCD and seven individual ASDs, including psoriasis (aHR 12.52; 95% CI 8.78-17.85), lichen planus (aHR 27.22; 95% CI 13.09-56.60), alopecia areata (aHR 13.69; 95% CI 9.38-19.98), autoimmune bullous diseases (aHR 4.30; 95% CI 2.03-9.11), hidradenitis suppurativa (aHR 29.95; 95% CI 3.35-267.62), vitiligo (aHR 9.35; 95% CI 5.35-16.32), and lupus erythematosus (aHR 2.10; 95% CI 1.52-2.91).CONCLUSIONS:
Patients with OCD had an increased risk of developing ASDs compared to matched controls. Further studies are required to clarify the underlying mechanisms.
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Bases de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Idioma:
En
Revista:
CNS Spectr
Asunto de la revista:
NEUROLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Taiwán