Implications of mitochondrial fusion and fission in skeletal muscle mass and health.
Semin Cell Dev Biol
; 143: 46-53, 2023 07 15.
Article
en En
| MEDLINE
| ID: mdl-35168898
ABSTRACT
The continuous dynamic reshaping of mitochondria by fusion and fission events is critical to keep mitochondrial quality and function under control in response to changes in energy and stress. Maintaining a functional, highly interconnected mitochondrial reticulum ensures rapid energy production and distribution. Moreover, mitochondrial networks act as dynamic signaling hub to adapt to the metabolic demands imposed by contraction, energy expenditure, and general metabolism. However, excessive mitochondrial fusion or fission results in the disruption of the skeletal muscle mitochondrial network integrity and activates a retrograde response from mitochondria to the nucleus, leading to muscle atrophy, weakness and influencing whole-body homeostasis. These actions are mediated via the secretion of mitochondrial-stress myokines such as FGF21 and GDF15. Here we will summarize recent discoveries in the role of mitochondrial fusion and fission in the control of muscle mass and in regulating physiological homeostasis and disease progression.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Músculo Esquelético
/
Dinámicas Mitocondriales
/
Mitocondrias Musculares
Límite:
Humans
Idioma:
En
Revista:
Semin Cell Dev Biol
Asunto de la revista:
EMBRIOLOGIA
Año:
2023
Tipo del documento:
Article