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Preclinical Characterization and Phase I Trial Results of a Bispecific Antibody Targeting PD-L1 and 4-1BB (GEN1046) in Patients with Advanced Refractory Solid Tumors.
Muik, Alexander; Garralda, Elena; Altintas, Isil; Gieseke, Friederike; Geva, Ravit; Ben-Ami, Eytan; Maurice-Dror, Corinne; Calvo, Emiliano; LoRusso, Patricia M; Alonso, Guzman; Rodriguez-Ruiz, Maria E; Schoedel, Kristina B; Blum, Jordan M; Sänger, Bianca; Salcedo, Theodora W; Burm, Saskia M; Stanganello, Eliana; Verzijl, Dennis; Vascotto, Fulvia; Sette, Angelica; Quinkhardt, Juliane; Plantinga, Theo S; Toker, Aras; van den Brink, Edward N; Fereshteh, Mark; Diken, Mustafa; Satijn, David; Kreiter, Sebastian; Breij, Esther C W; Bajaj, Gaurav; Lagkadinou, Eleni; Sasser, Kate; Türeci, Özlem; Forssmann, Ulf; Ahmadi, Tahamtan; Sahin, Ugur; Jure-Kunkel, Maria; Melero, Ignacio.
Afiliación
  • Muik A; BioNTech, Mainz, Germany.
  • Garralda E; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.
  • Altintas I; Genmab B.V., Utrecht, the Netherlands.
  • Gieseke F; BioNTech, Mainz, Germany.
  • Geva R; Oncology Division, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
  • Ben-Ami E; Department of Oncology, Chaim Sheba Medical Center, Ramat Gan, Israel.
  • Maurice-Dror C; Institute of Oncology, Rambam Health Care Campus, Haifa, Israel.
  • Calvo E; START Madrid-CIOCC, Clara Campal Comprehensive Cancer Center, Madrid, Spain.
  • LoRusso PM; Yale Cancer Center, Yale University, New Haven, Connecticut.
  • Alonso G; Medical Oncology Department, Vall d'Hebron University Hospital and Institute of Oncology, Barcelona, Spain.
  • Rodriguez-Ruiz ME; Radiation Oncology Department, Clínica Universidad de Navarra, Pamplona, Spain.
  • Schoedel KB; BioNTech, Mainz, Germany.
  • Blum JM; Genmab U.S. Inc., Princeton, New Jersey.
  • Sänger B; BioNTech, Mainz, Germany.
  • Salcedo TW; Genmab U.S. Inc., Princeton, New Jersey.
  • Burm SM; Genmab B.V., Utrecht, the Netherlands.
  • Stanganello E; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
  • Verzijl D; Genmab B.V., Utrecht, the Netherlands.
  • Vascotto F; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
  • Sette A; Genmab B.V., Utrecht, the Netherlands.
  • Quinkhardt J; BioNTech, Mainz, Germany.
  • Plantinga TS; Genmab B.V., Utrecht, the Netherlands.
  • Toker A; BioNTech, Mainz, Germany.
  • van den Brink EN; Genmab B.V., Utrecht, the Netherlands.
  • Fereshteh M; TRON gGmbH, Translational Oncology at the University Medical Center of the Johannes Gutenberg University, Mainz, Germany.
  • Diken M; BioNTech, Mainz, Germany.
  • Satijn D; Genmab B.V., Utrecht, the Netherlands.
  • Kreiter S; BioNTech, Mainz, Germany.
  • Breij ECW; Genmab B.V., Utrecht, the Netherlands.
  • Bajaj G; Genmab U.S. Inc., Princeton, New Jersey.
  • Lagkadinou E; BioNTech, Mainz, Germany.
  • Sasser K; Genmab U.S. Inc., Princeton, New Jersey.
  • Türeci Ö; BioNTech, Mainz, Germany.
  • Forssmann U; Genmab A/S, Copenhagen, Denmark.
  • Ahmadi T; Genmab U.S. Inc., Princeton, New Jersey.
  • Sahin U; BioNTech, Mainz, Germany.
  • Jure-Kunkel M; Genmab U.S. Inc., Princeton, New Jersey.
  • Melero I; Department of Immunology, Clínica Universidad de Navarra and CIBERONC, Pamplona, Spain.
Cancer Discov ; 12(5): 1248-1265, 2022 05 02.
Article en En | MEDLINE | ID: mdl-35176764

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2022 Tipo del documento: Article País de afiliación: Alemania

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anticuerpos Biespecíficos / Neoplasias Límite: Animals / Humans Idioma: En Revista: Cancer Discov Año: 2022 Tipo del documento: Article País de afiliación: Alemania