Ambroxol reverses tau and &#945;-synuclein accumulation in a cholinergic N370S GBA1 mutation model.

Yang, Shi Yu; Taanman, Jan-Willem; Gegg, Matthew; Schapira, Anthony H V

Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.

Yang, Shi Yu; Taanman, Jan-Willem; Gegg, Matthew; Schapira, Anthony H V.

Afiliación

Yang SY; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UK.
Taanman JW; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UK.
Gegg M; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UK.
Schapira AHV; Department of Clinical and Movement Neurosciences, Queen Square Institute of Neurology, University College London, Royal Free Campus, London NW3 2PF, UK.

Hum Mol Genet ; 31(14): 2396-2405, 2022 07 21.

Article en En | MEDLINE | ID: mdl-35179198

Asunto(s)

Ambroxol; Glucosilceramidasa; Enfermedad de Parkinson; Ambroxol/farmacología; Catepsina D/genética; Células Cultivadas; Colinérgicos/farmacología; Glucosilceramidasa/genética; Humanos; Mutación; Enfermedad de Parkinson/genética; Enfermedad de Parkinson/metabolismo; alfa-Sinucleína/genética; alfa-Sinucleína/metabolismo; Proteínas tau/genética; Proteínas tau/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Ambroxol / Glucosilceramidasa Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Hum Mol Genet Asunto de la revista: BIOLOGIA MOLECULAR / GENETICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

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