Beta-amyloid moderates the relationship between cortical thickness and attentional control in middle- and older-aged adults.
Neurobiol Aging
; 112: 181-190, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35227946
ABSTRACT
Although often unmeasured in studies of cognition, many older adults possess Alzheimer disease (AD) pathologies such as beta-amyloid (Aß) deposition, despite being asymptomatic. We were interested in examining whether the behavior-structure relationship observed in later life was altered by the presence of preclinical AD pathology. A total of 511 cognitively unimpaired adults completed magnetic resonance imaging and three attentional control tasks; a subset (n = 396) also underwent Aß-positron emissions tomography. A vertex-wise model was conducted to spatially represent the relationship between cortical thickness and average attentional control accuracy, while moderation analysis examined whether Aß deposition impacted this relationship. First, we found that reduced cortical thickness in temporal, medial- and lateral-parietal, and dorsolateral prefrontal cortex, predicted worse performance on the attention task composite. Subsequent moderation analyses observed that levels of Aß significantly influence the relationship between cortical thickness and attentional control. Our results support the hypothesis that preclinical AD, as measured by Aß deposition, is partially driving what would otherwise be considered general aging in a cognitively normal adult population.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Péptidos beta-Amiloides
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Enfermedad de Alzheimer
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Aged
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Humans
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Middle aged
Idioma:
En
Revista:
Neurobiol Aging
Año:
2022
Tipo del documento:
Article