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Dosage compensation in Bombyx mori is achieved by partial repression of both Z chromosomes in males.
Rosin, Leah F; Chen, Dahong; Chen, Yang; Lei, Elissa P.
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  • Rosin LF; Nuclear Organization and Gene Expression Section, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Chen D; Nuclear Organization and Gene Expression Section, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Chen Y; Nuclear Organization and Gene Expression Section, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
  • Lei EP; Nuclear Organization and Gene Expression Section, Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD 20892.
Proc Natl Acad Sci U S A ; 119(10): e2113374119, 2022 03 08.
Article en En | MEDLINE | ID: mdl-35239439
SignificanceGenes on sex chromosomes (i.e. human chX) are regulated differently in males and females to balance gene expression levels between sexes (XY vs. XX). This sex-specific regulation is called dosage compensation (DC). DC is achieved by altering the shape and compaction of sex chromosomes specifically in one sex. In this study, we use Oligopaints to examine DC in silkworms. This study visualizes this phenomenon in a species with ZW sex chromosomes, which evolved independently of XY. Our data support a long-standing model for how DC mechanisms evolved across species, and we show potential similarity between DC in silkworms and nematodes, suggesting that this type of DC may have emerged multiple independent times throughout evolution.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cromosomas Sexuales / Bombyx / Compensación de Dosificación (Genética) / Cromosomas de Insectos Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cromosomas Sexuales / Bombyx / Compensación de Dosificación (Genética) / Cromosomas de Insectos Límite: Animals Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article