Context-dependent regulation of follicular helper T cell survival.
Trends Immunol
; 43(4): 309-321, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35249831
ABSTRACT
Follicular helper T (TFH) cells are a specialized subset of CD4+ T cells that support germinal centers in producing high-affinity antibody-secreting and memory B cells in mammals and birds. Therefore, mechanisms have evolved to control the life and death of TFH cells for balanced humoral immunity. Recent studies have collectively revealed at least two programmed cell death pathways, ferroptosis and pyroptosis, which govern TFH cell survival under diverse physiopathological conditions including immunization, infection, gut homeostasis, and autoimmunity. We review major recent advances in our understanding of the context-dependent regulation of TFH cell survival via cell death pathways that are closely connected with cellular metabolism. Such knowledge might be applied to inform new strategies aimed at modulating humoral immunity, potentially including enhancement of vaccine efficacies.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Centro Germinal
/
Células T Auxiliares Foliculares
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2022
Tipo del documento:
Article