A serotonergic circuit regulates aversive associative learning under mitochondrial stress in C. elegans.
Proc Natl Acad Sci U S A
; 119(11): e2115533119, 2022 03 15.
Article
en En
| MEDLINE
| ID: mdl-35254908
ABSTRACT
SignificancePhysiological stress triggers avoidance behavior, allowing the animals to stay away from potential threats and optimize their chance of survival. Mitochondrial disruption, a common physiological stress in diverse species, induces the nematode Caenorhabditis elegans to avoid non-pathogenic bacteria through a serotonergic neuronal circuit. We find that distinct neurons, communicated through serotonin and a specific serotonin receptor, are required for the formation and retrieval of this learned aversive behavior. This learned avoidance behavior is associated with increased serotonin synthesis, altered neuronal response property, and reprogramming of locomotion patterns. The circuit and neuromodulatory mechanisms described here offer important insights for stress-induced avoidance behavior.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
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Serotonina
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Receptores de Serotonina
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Caenorhabditis elegans
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Neuronas Serotoninérgicas
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Mitocondrias
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Año:
2022
Tipo del documento:
Article