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Long-chain fatty acyl coenzyme A inhibits NME1/2 and regulates cancer metastasis.
Zhang, Shuai; Nelson, Ornella D; Price, Ian R; Zhu, Chengliang; Lu, Xuan; Fernandez, Irma R; Weiss, Robert S; Lin, Hening.
Afiliación
  • Zhang S; Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853.
  • Nelson OD; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Price IR; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Zhu C; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Lu X; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Fernandez IR; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Weiss RS; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853.
  • Lin H; Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853.
Proc Natl Acad Sci U S A ; 119(11): e2117013119, 2022 03 15.
Article en En | MEDLINE | ID: mdl-35259022
ABSTRACT
SignificanceThe study provided a long-sought molecular mechanism that could explain the link between fatty acid metabolism and cancer metastasis. Further understanding may lead to new strategies to inhibit cancer metastasis. The chemical proteomic approach developed here will be useful for discovering other regulatory mechanisms of protein function by small molecule metabolites.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Acilcoenzima A / Nucleósido Difosfato Quinasas NM23 / Neoplasias Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Acilcoenzima A / Nucleósido Difosfato Quinasas NM23 / Neoplasias Tipo de estudio: Etiology_studies Límite: Female / Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article