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Orally-active, clinically-translatable senolytics restore α-Klotho in mice and humans.
Zhu, Yi; Prata, Larissa G P Langhi; Gerdes, Erin O Wissler; Netto, Jair Machado Espindola; Pirtskhalava, Tamar; Giorgadze, Nino; Tripathi, Utkarsh; Inman, Christina L; Johnson, Kurt O; Xue, Ailing; Palmer, Allyson K; Chen, Tingjun; Schaefer, Kalli; Justice, Jamie N; Nambiar, Anoop M; Musi, Nicolas; Kritchevsky, Stephen B; Chen, Jun; Khosla, Sundeep; Jurk, Diana; Schafer, Marissa J; Tchkonia, Tamar; Kirkland, James L.
Afiliación
  • Zhu Y; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: Zhu.Yi@Mayo.edu.
  • Prata LGPL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Gerdes EOW; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Netto JME; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Pirtskhalava T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Giorgadze N; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Tripathi U; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Inman CL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Johnson KO; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Xue A; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Palmer AK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Chen T; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Schaefer K; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
  • Justice JN; Sticht Center for Healthy Aging and Alzheimer's Prevention, Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Nambiar AM; Division of Pulmonary Diseases and Critical Care Medicine, Department of Internal Medicine, University of Texas Health Sciences Center at San Antonio and South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
  • Musi N; Barshop Institute for Longevity and Aging Studies, Center for Healthy Aging, University of Texas Health Sciences Center at San Antonio and Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
  • Kritchevsky SB; Sticht Center for Healthy Aging and Alzheimer's Prevention, Internal Medicine, Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
  • Chen J; Division of Computational Biology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN 55905, USA.
  • Khosla S; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Division of Endocrinology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
  • Jurk D; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA; Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
  • Schafer MJ; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
  • Tchkonia T; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.
  • Kirkland JL; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA; Division of General Internal Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA. Elect
EBioMedicine ; 77: 103912, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35292270
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Envejecimiento / Senoterapéuticos Límite: Aged / Animals / Humans Idioma: En Revista: EBioMedicine Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Envejecimiento / Senoterapéuticos Límite: Aged / Animals / Humans Idioma: En Revista: EBioMedicine Año: 2022 Tipo del documento: Article