3D-Printed Polypyrrole Microneedle Arrays for Electronically Controlled Transdural Drug Release.
ACS Biomater Sci Eng
; 8(4): 1544-1553, 2022 04 11.
Article
en En
| MEDLINE
| ID: mdl-35294162
ABSTRACT
After the spinal cord injury, inflammation and cytotoxicity cause further damage to neural cells. The progression of this secondary injury might be reduced by the administration of anti-inflammatory drugs. To allow the local delivery of such drugs while minimizing dural opening, we have created a polypyrrole (PPy)-coated microneedle array using a microscale three-dimensional (3D) printing technology that facilitates electronically controlled encapsulation and the transdural release of drugs. PPy microneedles demonstrated an electronically controlled release of steroid dexamethasone (Dexa) in a novel in vitro transdural model and in vivo. The biological activity of the device was then tested by the electronic release of Dexa into an in vitro model of neuroinflammation, using activated microglia. Following electrically activated Dexa release, inflammation was reduced, as demonstrated by a decrease in nitric oxide and proinflammatory cytokines Il-6 and MCP-1. These results demonstrate the feasibility of PPy-coated microneedles for the transdural delivery of anti-inflammatory drugs to the central nervous system.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Polímeros
/
Pirroles
Límite:
Humans
Idioma:
En
Revista:
ACS Biomater Sci Eng
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos