The Purinosome: A Case Study for a Mammalian Metabolon.
Annu Rev Biochem
; 91: 89-106, 2022 06 21.
Article
en En
| MEDLINE
| ID: mdl-35320684
ABSTRACT
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex called the purinosome. In this review, we highlight our current understanding of the purinosome with emphasis on its biophysical properties and function and on the cellular mechanisms that regulate its assembly. We propose a model for functional purinosomes in which they consist of at least ten enzymes that localize near mitochondria and carry out de novo purine biosynthesis by metabolic channeling. We conclude by discussing challenges and opportunities associated with studying the purinosome and analogous metabolons.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Purinas
/
Mitocondrias
Límite:
Animals
Idioma:
En
Revista:
Annu Rev Biochem
Año:
2022
Tipo del documento:
Article