Autophagy Agents in Clinical Trials for Cancer Therapy: A Brief Review.
Curr Oncol
; 29(3): 1695-1708, 2022 03 05.
Article
en En
| MEDLINE
| ID: mdl-35323341
ABSTRACT
Autophagy has been of novel interest since it was first demonstrated to have effect in Burkitt's lymphoma. Since that time, the autophagy agents chloroquine and hydroxychloroquine have become the only FDA (Food and Drug Administration)-approved autophagy inhibitors. While not approved for cancer therapy, there are ongoing clinical trials to evaluate their safety and efficacy. Pevonedistat has emerged as a novel inhibitor through the neddylation pathway and is an autophagy activator. This paper summarizes and presents current clinical trials for hydroxychloroquine (HCQ), chloroquine (CQ), and Pevonedistat for the clinician.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hidroxicloroquina
/
Neoplasias
Límite:
Humans
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Curr Oncol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Canadá