Simvastatin Inhibits Tumor Growth and Migration by Mediating Caspase-1-Dependent Pyroptosis in Glioblastoma Multiforme.

Yang, Shulong; Xie, Chuncheng; Guo, Tieyun; Li, Huiying; Li, Nannan; Zhou, Song; Wang, Xiuyun; Xie, Chuncheng

Yang, Shulong; Xie, Chuncheng; Guo, Tieyun; Li, Huiying; Li, Nannan; Zhou, Song; Wang, Xiuyun; Xie, Chuncheng.

Afiliación

Yang S; Department of Pediatric Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Xie C; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Guo T; Department of Histology and Embryology, Basic Medical Science College, Harbin Medical University, Harbin, Heilongjiang Province, China.
Li H; Department of Central Operating Room, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Li N; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Zhou S; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Wang X; Department of Abdominal Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China.
Xie C; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China. Electronic address: xiechunchengHMU@hotmail.com.

World Neurosurg ; 165: e12-e21, 2022 09.

Article en En | MEDLINE | ID: mdl-35342027

Asunto(s)

Glioblastoma; MicroARNs; Caspasa 1/genética; Caspasa 1/metabolismo; Caspasa 1/farmacología; Glioblastoma/patología; Humanos; Hipolipemiantes/farmacología; MicroARNs/genética; Proteína con Dominio Pirina 3 de la Familia NLR/genética; Proteína con Dominio Pirina 3 de la Familia NLR/metabolismo; Nucleótidos; Piroptosis; ARN Mensajero; Simvastatina/farmacología; Simvastatina/uso terapéutico

Palabras clave

Caspase-1; Glioblastoma multiforme; Pyroptosis; Simvastatin; miR-214

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Glioblastoma / MicroARNs Límite: Humans Idioma: En Revista: World Neurosurg Asunto de la revista: NEUROCIRURGIA Año: 2022 Tipo del documento: Article País de afiliación: China

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