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Cerebellum anatomy predicts individual risk-taking behavior and risk tolerance.
Quan, Peng; He, Lisheng; Mao, Tianxin; Fang, Zhuo; Deng, Yao; Pan, Yu; Zhang, Xiaocui; Zhao, Ke; Lei, Hui; Detre, John A; Kable, Joseph W; Rao, Hengyi.
Afiliación
  • Quan P; Research Center for Quality of Life and Applied Psychology, Guangdong Medical University, Dongguan, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502, Richards Medical Research Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
  • He L; SILC Business School, Shanghai University, Shanghai, China.
  • Mao T; Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502
  • Fang Z; Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502
  • Deng Y; Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502
  • Pan Y; Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China.
  • Zhang X; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502, Richards Medical Research Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
  • Zhao K; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502, Richards Medical Research Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
  • Lei H; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502, Richards Medical Research Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
  • Detre JA; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502, Richards Medical Research Building, 3700 Hamilton Walk, Philadelphia, PA 19104, USA.
  • Kable JW; Department of Psychology, University of Pennsylvania, Philadelphia, PA, USA.
  • Rao H; Center for Magnetic Resonance Imaging Research and Key Laboratory of Applied Brain and Cognitive Sciences, School of Business and Management, Shanghai International Studies University, Shanghai, China; Center for Functional Neuroimaging, Department of Neurology, University of Pennsylvania, Room D502
Neuroimage ; 254: 119148, 2022 07 01.
Article en En | MEDLINE | ID: mdl-35346839
ABSTRACT
Human risk tolerance is highly idiosyncratic and individuals often show distinctive preferences when faced with similar risky situations. However, the neural underpinnings of individual differences in risk-taking remain unclear. Here we combined structural and perfusion MRI and examined the associations between brain anatomy and individual risk-taking behavior/risk tolerance in a sample of 115 healthy participants during the Balloon Analogue Risk Task, a well-established sequential risky decision paradigm. Both whole brain and region-of-interest analyses showed that the left cerebellum gray matter volume (GMV) has a strong association with individual risk-taking behavior and risk tolerance, outperforming the previously reported associations with the amygdala and right posterior parietal cortex (PPC) GMV. Left cerebellum GMV also accounted for risk tolerance and risk-taking behavior changes with aging. However, regional cerebral blood flow (CBF) provided no additional predictive power. These findings suggest a novel cerebellar anatomical contribution to individual differences in risk tolerance. Further studies are necessary to elucidate the underestimated important role of cerebellum in risk-taking.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Sustancia Gris Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Imagen por Resonancia Magnética / Sustancia Gris Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Neuroimage Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos