MDSCs and T cells in solid tumors and non-Hodgkin lymphomas: an immunosuppressive speech.
Clin Exp Immunol
; 208(2): 147-157, 2022 06 11.
Article
en En
| MEDLINE
| ID: mdl-35348617
ABSTRACT
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous subset of cells expanded during multiple pathological settings, including cancers. In tumors, MDSCs are dominant drivers of T-cell immunosuppression. To accomplish their job, they exploit multiple mechanisms ultimately leading to the paralysis of anti-tumor immunity. Among the variety of MDSC-ways of working within the tumor microenvironment, the generation of reactive species and the metabolic reprogramming have emerged as pivotal determinants of their immunosuppressive power. In this review we will overview integral mechanisms of MDSC-mediated immunosuppression in solid tumors, with a particular focus on Non-Hodgkin lymphoma.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfoma no Hodgkin
/
Células Supresoras de Origen Mieloide
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Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Immunol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia