Cytochrome P450-dependent drug oxidation activities and their expression levels in liver microsomes of chimeric TK-NOG mice with humanized livers.

Uehara, Shotaro; Yoneda, Nao; Higuchi, Yuichiro; Yamazaki, Hiroshi; Suemizu, Hiroshi

Uehara, Shotaro; Yoneda, Nao; Higuchi, Yuichiro; Yamazaki, Hiroshi; Suemizu, Hiroshi.

Afiliación

Uehara S; Central Institute for Experimental Animals, Kawasaki, Japan. Electronic address: s-uehara@ciea.or.jp.
Yoneda N; Central Institute for Experimental Animals, Kawasaki, Japan.
Higuchi Y; Central Institute for Experimental Animals, Kawasaki, Japan.
Yamazaki H; Laboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Machida, Japan.
Suemizu H; Central Institute for Experimental Animals, Kawasaki, Japan.

Drug Metab Pharmacokinet ; 44: 100454, 2022 Jun.

Article en En | MEDLINE | ID: mdl-35378494

Asunto(s)

Microsomas Hepáticos; Propafenona; Animales; Sistema Enzimático del Citocromo P-450/genética; Sistema Enzimático del Citocromo P-450/metabolismo; Hígado/metabolismo; Ratones; Microsomas Hepáticos/metabolismo; Oxidación-Reducción; Propafenona/metabolismo

Palabras clave

Chimeric TK-NOG mice With humanized liver; Cytochrome P450; Drug oxidation activity; Hepatic P450 content; Humanized liver mouse; NOG-TKm30 mouse; TK-NOG mouse

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Propafenona / Microsomas Hepáticos Límite: Animals Idioma: En Revista: Drug Metab Pharmacokinet Asunto de la revista: FARMACOLOGIA / METABOLISMO Año: 2022 Tipo del documento: Article

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