Lamins B2 Promotes Esophageal Cancer by Stimulating Proliferation and Inhibiting Apoptosis.

OBJECTIVE: To uncover the expression of Lamins B2 (LMNB2) in tumor tissues and the effects on the progression of esophageal cancer. MATERIALS AND METHODS: IHC assays were performed to detect the expression of LMNB2 in esophageal cancer tissues. Kaplan-Meier survival analysis was performed to confirm its effects on patients' prognosis. Colony formation, MTT, and Immunoblot assays were performed to confirm its effects on cell growth, and FCM assays were performed to show its effects on apoptosis. Tumor growth assays were conducted to assess the effects of LMNB2 on esophageal cancer progression in mice. RESULTS: LMNB2 expression was associated with the prognosis of esophageal cancer patients. Further in vitro and in vivo assays were performed and showed that LMNB2 was involved in the regulation of cell proliferation in esophageal cancer. Additionally, LMNB2 depletion contributed to the apoptosis of esophageal cancer cells. In conclusion, we demonstrate LMNB2 affects the development of esophageal cancer by promoting cell proliferation and inhibiting apoptosis. CONCLUSIONS: This study showed the involvement of LMNB2 in esophageal cancer progression in vitro and in vivo, and provides a novel therapeutic target for esophageal cancer.