Exosomes: A promising therapeutic strategy for intervertebral disc degeneration.
Exp Gerontol
; 163: 111806, 2022 06 15.
Article
en En
| MEDLINE
| ID: mdl-35417774
ABSTRACT
As a common problem all over the world, low back pain (LBP) places a huge social and economic burden on people. Intervertebral disc degeneration (IDD) is often considered to be the main cause of low back pain. The current methods of treating disc degenerative diseases mainly focus on relieving symptoms, including surgery and conservative treatment, but none of them can be treated with the etiology, which means that the normal structure of the intervertebral disc cannot be fundamentally restored. With the development of tissue engineering and regenerative medicine, exosomes from different sources, especially mesenchymal stem cell-derived exosomes (MSC-exos) as active biological substances for intercellular communication have made rapid progress due to their potency in promoting tissue regeneration. The study of exosomes in the field of treatment of IDD has yielded many surprising results. This paper mainly reviews the mechanism and function of exosomes in the study of delaying or reversing IDD, as well as gives the prospects and challenges of exosomes.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dolor de la Región Lumbar
/
Exosomas
/
Degeneración del Disco Intervertebral
/
Células Madre Mesenquimatosas
/
Disco Intervertebral
Límite:
Humans
Idioma:
En
Revista:
Exp Gerontol
Año:
2022
Tipo del documento:
Article
País de afiliación:
China