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Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self.
Chowdhury, Roshni Roy; D'Addabbo, Jessica; Huang, Xianxi; Veizades, Stefan; Sasagawa, Koki; Louis, David M; Cheng, Paul; Sokol, Jan; Jensen, Annie; Tso, Alexandria; Shankar, Vishnu; Wendel, Ben Shogo; Bakerman, Isaac; Liang, Grace; Koyano, Tiffany; Fong, Robyn; Nau, Allison N; Ahmad, Herra; Gopakumar, Jayakrishnan; Wirka, Robert; Lee, Andrew S; Boyd, Jack; Woo, Y Joseph; Quertermous, Thomas; Gulati, Gunsagar Singh; Jaiswal, Siddhartha; Chien, Yueh-Hsiu; Chan, Charles Kwok Fai; Davis, Mark M; Nguyen, Patricia K.
Afiliación
  • Chowdhury RR; Department of Microbiology and Immunology (R.R.C., Y.-H.C., M.M.D.), Stanford University, Stanford, CA, USA.
  • D'Addabbo J; CA, Department of Medicine, Section of Genetic Medicine, University of Chicago, Chicago' IL (R.R.C.).
  • Huang X; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Veizades S; Department of Cardiology, First Affiliated Hospital of Shantou University Medical College, Guangdong, China (X.H.).
  • Sasagawa K; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Louis DM; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Cheng P; Edinburgh Medical School, United Kingdom (S.V.).
  • Sokol J; Centre for Inflammation Research, University of Edinburgh, Scotland (S.V.).
  • Jensen A; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Tso A; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Shankar V; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Wendel BS; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Bakerman I; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Liang G; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Koyano T; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Fong R; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Nau AN; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Ahmad H; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Gopakumar J; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Wirka R; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Lee AS; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Boyd J; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Woo YJ; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Quertermous T; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Gulati GS; Department of Medicine, Cardiovascular Medicine (J.D., S.V., K.S., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., P.K.N.), Stanford University, Stanford, CA, USA.
  • Jaiswal S; Stanford Cardiovascular Institute (S.V., P.C., J.S., A.J., A.T., I.B., G.L., T.Q., C.K.F.C., P.K.N.), Stanford University, Stanford, CA, USA.
  • Chien YH; Department of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
  • Chan CKF; Department of Cardiothoracic Surgery (T.K., R.F., J.B., Y.J.W.), Stanford University, Stanford, CA, USA.
  • Davis MM; Institute for Immunity, Transplantation and Infection (D.M.L., A.J., A.T., V.S., B.S.W., A.N.N., P.K.N., M.M.D.), Stanford University, Stanford, CA, USA.
  • Nguyen PK; Department of Pathology (H.A., J.G., S.J.), Stanford University, Stanford, CA, USA.
Circ Res ; 130(10): 1510-1530, 2022 05 13.
Article en En | MEDLINE | ID: mdl-35430876
BACKGROUND: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies. METHODS: We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity. RESULTS: In addition to macrophages, we found a high proportion of αß T cells in the coronary plaques. Most of these T cells lack high expression of CCR7 and L-selectin, indicating that they are primarily antigen-experienced memory cells. Notably, nearly one-third of these cells express the HLA-DRA surface marker, signifying activation through their TCRs (T-cell receptors). Consistent with this, TCR repertoire analysis confirmed the presence of activated αß T cells (CD4
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Linfocitos T / Placa Aterosclerótica Límite: Humans Idioma: En Revista: Circ Res Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Linfocitos T / Placa Aterosclerótica Límite: Humans Idioma: En Revista: Circ Res Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos