Construction of Bridged Aza- and Oxa-[n.2.1] Skeletons via an Intramolecular Formal [3+2] Cycloaddition of Aziridines and Epoxides with Electron-Deficient Alkenes.
J Org Chem
; 87(9): 6426-6431, 2022 05 06.
Article
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| MEDLINE
| ID: mdl-35439001
ABSTRACT
An intramolecular formal [3+2] cycloaddition of activated aziridines and epoxides with electron-deficient alkene has been developed for the general and efficient construction of bridged aza- and oxa-[n.2.1] (n = 3 or 4) skeletons. This strategy can be efficiently promoted by lithium iodide. To demonstrate its potential, the intramolecular formal [3+2] cycloaddition was used to access the important intermediate of homoepiboxidine.
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Bases de datos:
MEDLINE
Asunto principal:
Aziridinas
/
Alquenos
Idioma:
En
Revista:
J Org Chem
Año:
2022
Tipo del documento:
Article