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Stereoselective Synthesis of ß-Glycinamide Ribonucleotide.
Ngu, Lisa; Ray, Debarpita; Watson, Samantha S; Beuning, Penny J; Ondrechen, Mary Jo; O'Doherty, George A.
Afiliación
  • Ngu L; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
  • Ray D; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
  • Watson SS; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
  • Beuning PJ; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
  • Ondrechen MJ; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
  • O'Doherty GA; Department of Chemistry, Northeastern University, Boston, MA 02115, USA.
Molecules ; 27(8)2022 Apr 14.
Article en En | MEDLINE | ID: mdl-35458726
A diastereoselective synthesis of the ß-anomer of glycinamide ribonucleotide (ß-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic ß-GAR formed was remarkably resistant to anomerization both in solution and as a solid.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transferasas de Hidroximetilo y Formilo Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transferasas de Hidroximetilo y Formilo Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos