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Effects of temporarily suspending low-dose methotrexate treatment for 2 weeks after SARS-CoV-2 vaccine booster on vaccine response in immunosuppressed adults with inflammatory conditions: protocol for a multicentre randomised controlled trial and nested mechanistic substudy (Vaccine Response On/Off Methotrexate (VROOM) study).
Abhishek, Abhishek; Boyton, R J; McKnight, Áine; Coates, Laura; Bluett, James; Barber, Vicki S; Cureton, Lucy; Francis, Anne; Appelbe, Duncan; Eldridge, Lucy; Julier, Patrick; Peckham, Nicholas; Valdes, Ana M; Rombach, Ines; Altmann, Daniel M; Nguyen-Van-Tam, Jonathan; Williams, Hywel C; Cook, Jonathan Alistair.
Afiliación
  • Abhishek A; Academic Rheumatology, University of Nottingham, Nottingham, UK Abhishek.abhishek@nottingham.ac.uk.
  • Boyton RJ; Department of Infectious Diseases, Imperial College London, London, UK.
  • McKnight Á; Lung Division, Royal Brompton and Harefield Hospitals, London, London.
  • Coates L; Blizard Institute, Centre for Genomics and Child Health, Queen Mary University of London, London, UK.
  • Bluett J; NDORMS, University of Oxford, Oxford, UK.
  • Barber VS; Manchester Academic Health Science Centre, Manchester, UK.
  • Cureton L; The University of Manchester, Manchester, UK.
  • Francis A; NDORMS, University of Oxford, Oxford, UK.
  • Appelbe D; Oxford Clinical Trials Unit, Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, UK.
  • Eldridge L; NDORMS, University of Oxford, Oxford, UK.
  • Julier P; Oxford Clinical Trials Unit, Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, UK.
  • Peckham N; NDORMS, University of Oxford, Oxford, UK.
  • Valdes AM; Oxford Clinical Trials Unit, Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, UK.
  • Rombach I; NDORMS, University of Oxford, Oxford, UK.
  • Altmann DM; Oxford Clinical Trials Unit, Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, UK.
  • Nguyen-Van-Tam J; NDORMS, University of Oxford, Oxford, UK.
  • Williams HC; Oxford Clinical Trials Unit, Department of Orthopaedics Rheumatology and Musculoskeletal Sciences, University of Oxford Nuffield, Oxford, UK.
  • Cook JA; NDORMS, University of Oxford, Oxford, UK.
BMJ Open ; 12(5): e062599, 2022 05 03.
Article en En | MEDLINE | ID: mdl-35504634

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vacunas / COVID-19 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Vacunas / COVID-19 / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Clinical_trials / Guideline / Observational_studies / Prognostic_studies Límite: Humans Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article