Enantioselective one-pot synthesis of 4H-chromene derivatives catalyzed by a chiral Ni(ii) complex.
RSC Adv
; 10(72): 44437-44441, 2020 Dec 09.
Article
en En
| MEDLINE
| ID: mdl-35517147
ABSTRACT
A Ni(ii)-bis(oxazoline) complex and p-TSOH are used to form enantioenriched 4H-chromenes from ortho-quinone methides (o-QMs) and dicarbonyls, providing the desired products in up to 95% ee. The method is compatible with various ß-ketoester substrates, and the products obtained could be converted into biologically active 4H-chromene derivatives.
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RSC Adv
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2020
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Article