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Regioselective Access to 2-Iminoimidazolidines via AgF-Mediated Cascade Reactions.
He, Yiting; Wu, Haiting; Liang, Yunshi; Deng, Huiying; Xiang, Lingling; Gu, Jiangyong; Zhang, Jing.
Afiliación
  • He Y; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
  • Wu H; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
  • Liang Y; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
  • Deng H; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
  • Xiang L; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
  • Gu J; Research Centre for Integrative Medicine, School of Basic Medical Science, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • Zhang J; Artemisinin Research Center & The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
J Org Chem ; 87(11): 7480-7486, 2022 06 03.
Article en En | MEDLINE | ID: mdl-35549272
ABSTRACT
A convergent access to substituted 2-iminoimidazolidines from aromatic amines and N-propargyl S-methylthiourea is developed via Ag(I)-mediated cascade guanylation-cyclization reactions. This method features high regioselectivity, excellent efficiency, and mild reaction conditions. Subsequent deprotection of the Boc (tert-butyloxycarbonyl) group under acidic conditions provides expedient access to aryl 2-aminoimidazole derivatives in a convenient manner.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aminas Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Aminas Idioma: En Revista: J Org Chem Año: 2022 Tipo del documento: Article País de afiliación: China