A novel solid phase extraction sample preparation method for sensitively determining doxepin and <i>N</i>-nordoxepin in human plasma and its application in a bioequivalence study in healthy Chinese volunteers.

Zheng, Binjie; Chen, Lulu; Zheng, Tiandong; Hou, Liping; Huang, Xinyi; Li, Chao; Wang, Xintong; Fang, Qing; Chen, Jie; Tang, Zhi; Li, Zhenyu; Ouyang, Dongsheng

A novel solid phase extraction sample preparation method for sensitively determining doxepin and N-nordoxepin in human plasma and its application in a bioequivalence study in healthy Chinese volunteers.

Zheng, Binjie; Chen, Lulu; Zheng, Tiandong; Hou, Liping; Huang, Xinyi; Li, Chao; Wang, Xintong; Fang, Qing; Chen, Jie; Tang, Zhi; Li, Zhenyu; Ouyang, Dongsheng.

Afiliación

Zheng B; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P. R. China. ouyangyj@163.com.
Chen L; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P. R. China.
Zheng T; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China.
Hou L; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd, Changsha, China. zhi.tang@duxact.com.
Huang X; Hunan Changsha Duxact Clinical Laboratory Co., Ltd, Changsha Duxact Biotech Co., Ltd, Changsha, China.
Li C; School of Pharmacy, Xiangnan University, Chenzhou 423000, China.
Wang X; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd, Changsha, China. zhi.tang@duxact.com.
Fang Q; Hunan Changsha Duxact Clinical Laboratory Co., Ltd, Changsha Duxact Biotech Co., Ltd, Changsha, China.
Chen J; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha Duxact Biotech Co., Ltd, Changsha, China. zhi.tang@duxact.com.
Tang Z; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha 410008, P. R. China. ouyangyj@163.com.
Li Z; Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, 110 Xiangya Road, Changsha 410078, P. R. China.
Ouyang D; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education, 110 Xiangya Road, Changsha 410078, P. R. China.

Anal Methods ; 14(22): 2168-2178, 2022 06 09.

Article en En | MEDLINE | ID: mdl-35608048

Asunto(s)

Doxepina; Espectrometría de Masas en Tándem; China; Cromatografía Líquida de Alta Presión/métodos; Cromatografía Liquida/métodos; Doxepina/análogos & derivados; Voluntarios Sanos; Humanos; Reproducibilidad de los Resultados; Extracción en Fase Sólida/métodos; Espectrometría de Masas en Tándem/métodos; Equivalencia Terapéutica

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Doxepina / Espectrometría de Masas en Tándem Tipo de estudio: Diagnostic_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Anal Methods Año: 2022 Tipo del documento: Article

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