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Transient Introgression of Wolbachia into Aedes aegypti Populations Does Not Elicit an Antibody Response to Wolbachia Surface Protein in Community Members.
Lee, Elvina; Hien Nguyen, Tran; Yen Nguyen, Thu; Nam Vu, Sinh; Duong Tran, Nhu; Trung Nghia, Le; Mai Vien, Quang; Dong Nguyen, Thanh; Kriiger Loterio, Robson; Iturbe-Ormaetxe, Iñaki; Flores, Heather A; O'Neill, Scott L; Anh Dang, Duc; Simmons, Cameron P; Fraser, Johanna E.
Afiliación
  • Lee E; Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • Hien Nguyen T; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
  • Yen Nguyen T; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
  • Nam Vu S; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
  • Duong Tran N; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
  • Trung Nghia L; Institute Pasteur, Nha Trang 650000, Vietnam.
  • Mai Vien Q; Institute Pasteur, Nha Trang 650000, Vietnam.
  • Dong Nguyen T; Institute Pasteur, Nha Trang 650000, Vietnam.
  • Kriiger Loterio R; Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • Iturbe-Ormaetxe I; World Mosquito Program, Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • Flores HA; Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • O'Neill SL; World Mosquito Program, Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • Anh Dang D; National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
  • Simmons CP; World Mosquito Program, Institute of Vector-Borne Disease, Monash University, Clayton, VIC 3800, Australia.
  • Fraser JE; Oxford University Clinical Research Unit, Ho Chi Minh City 710400, Vietnam.
Pathogens ; 11(5)2022 May 03.
Article en En | MEDLINE | ID: mdl-35631057
Wolbachia is an endosymbiotic bacterium that can restrict the transmission of human pathogenic viruses by Aedes aegypti mosquitoes. Recent field trials have shown that dengue incidence is significantly reduced when Wolbachia is introgressed into the local Ae. aegypti population. Female Ae. aegypti are anautogenous and feed on human blood to produce viable eggs. Herein, we tested whether people who reside on Tri Nguyen Island (TNI), Vietnam developed antibodies to Wolbachia Surface Protein (WSP) following release of Wolbachia-infected Ae. aegypti, as a measure of exposure to Wolbachia. Paired blood samples were collected from 105 participants before and after mosquito releases and anti-WSP titres were measured by ELISA. We determined no change in anti-WSP titres after ~30 weeks of high levels of Wolbachia-Ae. aegypti on TNI. These data suggest that humans are not exposed to the major Wolbachia surface antigen, WSP, following introgression of Wolbachia-infected Ae. aegypti mosquitoes.
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Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2022 Tipo del documento: Article País de afiliación: Australia

Texto completo: 1 Bases de datos: MEDLINE Idioma: En Revista: Pathogens Año: 2022 Tipo del documento: Article País de afiliación: Australia