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MAP3K Family Review and Correlations with Patient Survival Outcomes in Various Cancer Types.
Nguyen, Khoa; Tran, Minh N; Rivera, Andrew; Cheng, Thomas; Windsor, Gabrielle O; Chabot, Abraham B; Cavanaugh, Jane E; Collins-Burow, Bridgette M; Lee, Sean B; Drewry, David H; Flaherty, Patrick T; Burow, Matthew E.
Afiliación
  • Nguyen K; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Tran MN; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Rivera A; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Cheng T; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Windsor GO; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Chabot AB; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Cavanaugh JE; Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA.
  • Collins-Burow BM; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Lee SB; Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
  • Drewry DH; UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chemical Biology and Medicinal Chemistry Division, SGC-UNC, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Flaherty PT; Department of Pharmacological Sciences, Division of Medicinal Chemistry, Mylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15218, USA.
  • Burow ME; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Front Biosci (Landmark Ed) ; 27(5): 167, 2022 05 23.
Article en En | MEDLINE | ID: mdl-35638434
ABSTRACT
The mitogen-activated protein kinase (MAPK) pathways are ubiquitous in cellular signaling and are essential for proper biological functions. Disruptions in this signaling axis can lead to diseases such as the development of cancer. In this review, we discuss members of the MAP3K family and correlate their mRNA expression levels to patient survival outcomes in different cancers. Furthermore, we highlight the importance of studying the MAP3K family due to their important roles in the larger, overall MAPK pathway, relationships with cancer progression, and the understudied status of these kinases.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Neoplasias Límite: Humans Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
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Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sistema de Señalización de MAP Quinasas / Neoplasias Límite: Humans Idioma: En Revista: Front Biosci (Landmark Ed) Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos