Lipid-Drug Conjugates and Nanoparticles for the Cutaneous Delivery of Cannabidiol.
Int J Mol Sci
; 23(11)2022 May 31.
Article
en En
| MEDLINE
| ID: mdl-35682847
ABSTRACT
Lipid nanoparticles are currently used to deliver drugs to specific sites in the body, known as targeted therapy. Conjugates of lipids and drugs to produce drug-enriched phospholipid micelles have been proposed to increase the lipophilic character of drugs to overcome biological barriers. However, their applicability at the topical level is still minimal. Phospholipid micelles are amphiphilic colloidal systems of nanometric dimensions, composed of a lipophilic nucleus and a hydrophilic outer surface. They are currently used successfully as pharmaceutical vehicles for poorly water-soluble drugs. These micelles have high in vitro and in vivo stability and high biocompatibility. This review discusses the use of lipid-drug conjugates as biocompatible carriers for cutaneous application. This work provides a metadata analysis of publications concerning the conjugation of cannabidiol with lipids as a suitable approach and as a new delivery system for this drug.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Cannabidiol
/
Nanopartículas
Idioma:
En
Revista:
Int J Mol Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
Polonia