General anesthesia and the cortical stranglehold on consciousness.

Pal, Dinesh; Mashour, George A

Pal, Dinesh; Mashour, George A.

Afiliación

Pal D; Department of Anesthesiology, Center for Consciousness Science, Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
Mashour GA; Department of Anesthesiology, Center for Consciousness Science, Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA; Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: gmashour@umich.edu.

Neuron ; 110(12): 1891-1893, 2022 06 15.

Article en En | MEDLINE | ID: mdl-35709695

ABSTRACT

ABSTRACT

In this issue of Neuron, Bharioke et al. (2022) demonstrate that diverse general anesthetic regimens all reversibly and selectively synchronize spontaneous activity of pyramidal neurons in layer 5 of mouse cortex. We discuss the implications of these findings for the mechanism of consciousness and anesthetic-induced unconsciousness.

Asunto(s)

Anestésicos Generales; Estado de Conciencia; Anestesia General; Anestésicos Generales/farmacología; Animales; Estado de Conciencia/fisiología; Electroencefalografía; Ratones; Neuronas/fisiología; Inconsciencia/inducido químicamente

Palabras clave

consciousness; cortex; general anesthesia; layer 5; neuronal synchrony

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Anestésicos Generales / Estado de Conciencia Límite: Animals Idioma: En Revista: Neuron Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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