Modeling Susceptibility to Cardiotoxicity in Cancer Therapy Using Human iPSC-Derived Cardiac Cells and Systems Biology.
Heart Fail Clin
; 18(3): 335-347, 2022 Jul.
Article
en En
| MEDLINE
| ID: mdl-35718410
ABSTRACT
The development of human-induced pluripotent stem cell-derived cardiac cell types has created a new paradigm in assessing drug-induced cardiotoxicity. Advances in genomics and epigenomics have also implicated several genomic loci and biological pathways that may contribute to susceptibility to cancer therapies. In this review, we first provide a brief overview of the cardiotoxicity associated with chemotherapy. We then provide a detailed summary of systems biology approaches being applied to elucidate potential molecular mechanisms involved in cardiotoxicity. Finally, we discuss combining systems biology approaches with iPSC technology to help discover molecular mechanisms associated with cardiotoxicity.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Células Madre Pluripotentes Inducidas
/
Neoplasias
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Heart Fail Clin
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos