circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop.

Li, Xiaomin; Wang, Jianjun; Lin, Weihao; Yuan, Qinzi; Lu, Yanxia; Wang, Haowei; Chen, Yujia; Chen, Lixia; Dai, Peiling; Long, Huaicheng; Li, Xuenong

Li, Xiaomin; Wang, Jianjun; Lin, Weihao; Yuan, Qinzi; Lu, Yanxia; Wang, Haowei; Chen, Yujia; Chen, Lixia; Dai, Peiling; Long, Huaicheng; Li, Xuenong.

Afiliación

Li X; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Department of Pathology, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Wang J; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Lin W; Department of Histology and Embryology, Wannan Medical College, Wuhu, 241002, Anhui Province, China.
Yuan Q; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Department of Pathology, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Lu Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Wang H; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Department of Pathology, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Chen Y; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Chen L; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Department of Pathology, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Dai P; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Long H; Guangdong Province Key Laboratory of Molecular Tumor Pathology, Department of Pathology, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.
Li X; Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong Province, China.

Mol Cancer ; 21(1): 135, 2022 06 23.

Article en En | MEDLINE | ID: mdl-35739524

Asunto(s)

Neoplasias Colorrectales; Proteínas de Unión al GTP Monoméricas; ARN Circular; Línea Celular Tumoral; Proliferación Celular/genética; Neoplasias Colorrectales/tratamiento farmacológico; Neoplasias Colorrectales/genética; Neoplasias Colorrectales/metabolismo; Retroalimentación; Fluorouracilo/farmacología; Regulación Neoplásica de la Expresión Génica; Humanos; Subunidad alfa del Factor 1 Inducible por Hipoxia/genética; Subunidad alfa del Factor 1 Inducible por Hipoxia/metabolismo; Hibridación Fluorescente in Situ; Diana Mecanicista del Complejo 1 de la Rapamicina/genética; Proteínas de Unión al GTP Monoméricas/genética; Proteínas de Unión al GTP Monoméricas/metabolismo; ARN Circular/genética

Palabras clave

Circular RNA; Colorectal cancer; RRAGB; circEXOC6B; hsa_circ_0009043

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Colorrectales / Proteínas de Unión al GTP Monoméricas / ARN Circular Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Mol Cancer Asunto de la revista: NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: China

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