Lignans and a neolignan from an aqueous extract of Isatis indigotica roots.
J Asian Nat Prod Res
; : 1-13, 2022 Jun 24.
Article
en En
| MEDLINE
| ID: mdl-35749256
ABSTRACT
Four new lignans (1-4) and one new neolignan (5), along with two known lignan derivatives (6 and 7), were isolated from an aqueous extract of the Isatis indigotica root (ban lan gen). Their structures were determined by spectroscopic data analysis, chemical method, and theoretical calculation, for which 1 was proved by single-crystal X-ray diffraction. Compound 2 exhibited antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with an IC50 value of 11.1 µM and a selective index (SI) > 9, while 1 and 5 are the first examples of sulfonated lignan and neolignan from nature.
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Bases de datos:
MEDLINE
Idioma:
En
Revista:
J Asian Nat Prod Res
Asunto de la revista:
BOTANICA
/
QUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China