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Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state.
Miller, Peter G; Sathappa, Murugappan; Moroco, Jamie A; Jiang, Wei; Qian, Yue; Iqbal, Sumaiya; Guo, Qi; Giacomelli, Andrew O; Shaw, Subrata; Vernier, Camille; Bajrami, Besnik; Yang, Xiaoping; Raffier, Cerise; Sperling, Adam S; Gibson, Christopher J; Kahn, Josephine; Jin, Cyrus; Ranaghan, Matthew; Caliman, Alisha; Brousseau, Merissa; Fischer, Eric S; Lintner, Robert; Piccioni, Federica; Campbell, Arthur J; Root, David E; Garvie, Colin W; Ebert, Benjamin L.
Afiliación
  • Miller PG; Center for Cancer Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Sathappa M; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Moroco JA; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Jiang W; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Qian Y; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Iqbal S; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Guo Q; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Giacomelli AO; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Shaw S; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Vernier C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Bajrami B; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Yang X; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Raffier C; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Sperling AS; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Gibson CJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Kahn J; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Jin C; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Ranaghan M; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Caliman A; Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Brousseau M; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Fischer ES; Department of Internal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Lintner R; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Piccioni F; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • Campbell AJ; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Root DE; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Garvie CW; Center for the Development of Therapeutics, Broad Institute of MIT and Harvard University, Cambridge, MA, USA.
  • Ebert BL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nat Commun ; 13(1): 3778, 2022 06 30.
Article en En | MEDLINE | ID: mdl-35773251
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína Fosfatasa 2C / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteína Fosfatasa 2C / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos