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PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Godinho, Bruno M D C; Knox, Emily G; Hildebrand, Samuel; Gilbert, James W; Echeverria, Dimas; Kennedy, Zachary; Haraszti, Reka A; Ferguson, Chantal M; Coles, Andrew H; Biscans, Annabelle; Caiazzi, Jillian; Alterman, Julia F; Hassler, Matthew R; Khvorova, Anastasia.
Afiliación
  • Godinho BMDC; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Knox EG; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Hildebrand S; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Gilbert JW; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Echeverria D; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Kennedy Z; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Haraszti RA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Ferguson CM; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Coles AH; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Biscans A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Caiazzi J; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Hassler MR; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
Mol Ther Nucleic Acids ; 29: 116-132, 2022 Sep 13.
Article en En | MEDLINE | ID: mdl-35795486
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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Ther Nucleic Acids Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Mol Ther Nucleic Acids Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos