Current understanding of MSC-derived exosomes in the management of knee osteoarthritis.
Exp Cell Res
; 418(2): 113274, 2022 09 15.
Article
en En
| MEDLINE
| ID: mdl-35810774
ABSTRACT
Mesenchymal stem cell-derived exosomes (MSC-Exos) have been utilized as medicinal agents or as delivery vehicles in cartilage injuries and cartilage-based diseases. Given the ongoing emergence of evidence on the effector mechanisms and methods of the utility of the MSC-Exos in knee osteoarthritis, a comprehensive review of the current evidence is the need of the hour. Hence, in this article, we review the current understanding of the role of MSC-Exos in the management of knee osteoarthritis in view of their classification, characterization, biogenesis, mechanism of action, pathways involved in their therapeutic action, in-vitro evidence on cartilage regeneration, in-vivo evidence in OA knee models and recent advances in using MSC-Exos to better streamline future research from bench to bedside for OA knee.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Osteoartritis de la Rodilla
/
Exosomas
/
Células Madre Mesenquimatosas
Límite:
Humans
Idioma:
En
Revista:
Exp Cell Res
Año:
2022
Tipo del documento:
Article