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Molecular profile of head and neck rhabdomyosarcomas: A systematic review and meta-analysis.
Gallagher, Karen Patricia Domínguez; van Heerden, Willie; Said-Al-Naief, Nasser; Carlos, Roman; Arboleda, Lady Paola Aristizabal; Rodrigues-Fernandes, Carla Isabelly; Araújo, Anna Luíza Damaceno; Fonseca, Felipe Paiva; Pontes, Hélder Antônio Rebelo; Innocentini, Lara Maria Alencar Ramos; Romañach, Mário José; Vargas, Pablo Agustin; Lopes, Márcio Ajudarte; Santos-Silva, Alan Roger; Khurram, Syed Ali.
Afiliación
  • Gallagher KPD; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil; Practicing Graduate Professor, School of Dentistry, National University of Asunción (UNA), Asunción, Paraguay.
  • van Heerden W; Department of Oral Pathology and Oral Biology, School of Dentistry, University of Pretoria, South Africa.
  • Said-Al-Naief N; Professor, Oral and Maxillofacial Pathology, Oregon Health and Science University, School of Dentistry and School of Medicine, OR, USA.
  • Carlos R; Department of Pathology, Integra Cancer Center, Guatemala City, Guatemala.
  • Arboleda LPA; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Rodrigues-Fernandes CI; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Araújo ALD; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Fonseca FP; Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil.
  • Pontes HAR; Oral Pathology Department, João de Barros Barreto University Hospital, Federal University of Pará, Belém, Pará, Brazil.
  • Innocentini LMAR; Dentistry and Stomatology Division, Ophthalmology, Otolaryngology and Head and Neck Surgery Department, University Hospital of the Ribeirão Preto Medical School, University of São Paulo, SP, Brazil.
  • Romañach MJ; Department of Oral Diagnosis and Pathology, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Vargas PA; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Lopes MA; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
  • Santos-Silva AR; Oral Diagnosis Department, Semiology and Oral Pathology Areas, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil. Electronic address: alanroger@fop.unicamp.br.
  • Khurram SA; Unit of Oral & Maxillofacial Pathology, School of Clinical Dentistry, University of Sheffield, Sheffield, UK.
Oral Surg Oral Med Oral Pathol Oral Radiol ; 134(3): 354-366, 2022 09.
Article en En | MEDLINE | ID: mdl-35840496
ABSTRACT

OBJECTIVE:

This systematic review aimed to identify the molecular alterations of head and neck rhabdomyosarcomas (HNRMS) and their prognostic values. STUDY

DESIGN:

An electronic search was performed using PubMed, Embase, Scopus, and Web of Science with a designed search strategy. Inclusion criteria comprised cases of primary HNRMS with an established histopathological diagnosis and molecular analysis. Forty-nine studies were included and were appraised for methodological quality using the Joanna Briggs Institute Critical Appraisal tools. Five studies were selected for meta-analysis.

RESULTS:

HNRMS predominantly affects pediatric patients (44.4%), and the parameningeal region (57.7%) is the most common location. The alveolar variant (43.2%) predominates over the embryonal and spindle cell/sclerosing types, followed by the epithelioid and pleomorphic variants. PAX-FOXO1 fusion was observed in 103 cases of alveolar RMS (79.8%). MYOD1 mutation was found in 39 cases of sclerosing/spindle cell RMS (53.4%). FUS/EWSR1-TFCP2 gene fusions were identified in 21 cases of RMS with epithelioid and spindle cell morphologies (95.5%). The 5-year overall survival rate of patients was 61.3%, and MYOD1 mutation correlated with significantly higher mortality.

CONCLUSION:

The genotypic profile of histologic variants of HNRMS is widely variable, and MYOD1 mutation could be a potential prognostic factor, but more studies are required to establish this.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Rabdomiosarcoma Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Año: 2022 Tipo del documento: Article País de afiliación: Paraguay
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Rabdomiosarcoma Tipo de estudio: Prognostic_studies / Systematic_reviews Límite: Child / Humans Idioma: En Revista: Oral Surg Oral Med Oral Pathol Oral Radiol Año: 2022 Tipo del documento: Article País de afiliación: Paraguay