Long-Term Functional Outcomes of an Anorectal Malformation French National Cohort.
J Pediatr Gastroenterol Nutr
; 74(6): 782-787, 2022 06 01.
Article
en En
| MEDLINE
| ID: mdl-35849503
ABSTRACT
OBJECTIVES:
The present study aimed to assess long-term functional outcomes of children with anorectal malformations (ARMs) across a network of expert centers in France.METHODS:
Retrospective cross-sectional study of patients ages 6-30âyears that had been surgically treated for ARM. Patient and ARM characteristics (eg, level, surgical approach) and functional outcomes were assessed in the different age groups.RESULTS:
Among 367 patients, there were 155 females (42.2%) and 212 males (57.8%), 188 (51.2%) cases with, and 179 (48.8%) higher forms without, perineal fistula. Univariate and multivariate statistical analyses with logistic regression showed correlation between the level of the rectal blind pouch and voluntary bowel movements (odds ratio [OR]â=â1.84 [1.31-2.57], Pâ<â0.001), or soiling (ORâ=â1.72 [1.31-2.25], Pâ<â0.001), which was also associated with the inability to discriminate between stool and gas (ORâ=â2.45 [1.28-4.67], Pâ=â0.007) and the presence of constipation (ORâ=â2.97 [1.74-5.08], Pâ<â0.001). Risk factors for constipation were sacral abnormalities [ORâ=â2.26 [1.23-4.25], Pâ=â0.01) and surgical procedures without an abdominal approach (ORâ=â2.98 [1.29-6.87], Pâ=â0.01). Only the holding of voluntary bowel movements and soiling rates improved with age.CONCLUSION:
This cross-sectional study confirms a strong association between anatomical status and functional outcomes in patients surgically treated for ARM. It specifically highlights the need for long-term follow-up of all patients to help them with supportive care.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Malformaciones Anorrectales
Tipo de estudio:
Etiology_studies
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
J Pediatr Gastroenterol Nutr
Año:
2022
Tipo del documento:
Article