Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner.

Liao, Yihan; Ren, Yinshi; Luo, Xin; Mirando, Anthony J; Long, Jason T; Leinroth, Abigail; Ji, Ru-Rong; Hilton, Matthew J

Liao, Yihan; Ren, Yinshi; Luo, Xin; Mirando, Anthony J; Long, Jason T; Leinroth, Abigail; Ji, Ru-Rong; Hilton, Matthew J.

Afiliación

Liao Y; Departments of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Ren Y; Departments of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.
Luo X; Departments of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.
Mirando AJ; Center for Translational Pain Medicine, Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA.
Long JT; Departments of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.
Leinroth A; Departments of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.
Ji RR; Department of Cell Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Hilton MJ; Departments of Orthopaedic Surgery, Duke Orthopaedic Cellular, Developmental, and Genome Laboratories, Duke University School of Medicine, Durham, NC 27710, USA.

Sci Signal ; 15(744): eabn7082, 2022 07 26.

Article en En | MEDLINE | ID: mdl-35881692

Asunto(s)

Cartílago Articular; Osteoartritis; Animales; Cartílago Articular/metabolismo; Condrocitos/metabolismo; Femenino; Interleucina-6/metabolismo; Masculino; Ratones; Osteoartritis/genética; Dolor/metabolismo

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteoartritis / Cartílago Articular Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Sci Signal Asunto de la revista: CIENCIA / FISIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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