Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1&#945; promoters and isoforms regulated distinctly in myocardial ischemia and obesity.

Oehler, Daniel; Spychala, André; Gödecke, Axel; Lang, Alexander; Gerdes, Norbert; Ruas, Jorge; Kelm, Malte; Szendroedi, Julia; Westenfeld, Ralf

Full-length transcriptomic analysis in murine and human heart reveals diversity of PGC-1α promoters and isoforms regulated distinctly in myocardial ischemia and obesity.

Oehler, Daniel; Spychala, André; Gödecke, Axel; Lang, Alexander; Gerdes, Norbert; Ruas, Jorge; Kelm, Malte; Szendroedi, Julia; Westenfeld, Ralf.

Afiliación

Oehler D; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany. Daniel.Oehler@med.uni-duesseldorf.de.
Spychala A; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany. Daniel.Oehler@med.uni-duesseldorf.de.
Gödecke A; Department of Cardiovascular Physiology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Lang A; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Gerdes N; Department of Cardiovascular Physiology, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany.
Ruas J; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
Kelm M; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.
Szendroedi J; Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, Heinrich-Heine University, Moorenstr. 5, 40225, Düsseldorf, Germany.
Westenfeld R; Cardiovascular Research Institute Düsseldorf (CARID), Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany.

BMC Biol ; 20(1): 169, 2022 07 30.

Article en En | MEDLINE | ID: mdl-35907957

Asunto(s)

Isquemia Miocárdica; Transcriptoma; Empalme Alternativo; Animales; Humanos; Ratones; Isquemia Miocárdica/genética; Obesidad/genética; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/genética; Coactivador 1-alfa del Receptor Activado por Proliferadores de Peroxisomas gamma/metabolismo; Isoformas de Proteínas/genética; ARN Mensajero/metabolismo

Palabras clave

Diet-induced obesity; Ischemia/reperfusion; Long-read sequencing; PGC-1α

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Isquemia Miocárdica / Transcriptoma Límite: Animals / Humans Idioma: En Revista: BMC Biol Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Alemania

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