Elucidation of the tyrosinase/O<sub>2</sub>/monophenol ternary intermediate that dictates the monooxygenation mechanism in melanin biosynthesis.

Kipouros, Ioannis; Stanczak, Agnieszka; Ginsbach, Jake W; Andrikopoulos, Prokopis C; Rulísek, Lubomír; Solomon, Edward I

Elucidation of the tyrosinase/O₂/monophenol ternary intermediate that dictates the monooxygenation mechanism in melanin biosynthesis.

Kipouros, Ioannis; Stanczak, Agnieszka; Ginsbach, Jake W; Andrikopoulos, Prokopis C; Rulísek, Lubomír; Solomon, Edward I.

Afiliación

Kipouros I; Department of Chemistry, Stanford University, Stanford, CA 94305.
Stanczak A; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 166 10, Prague 6, Czech Republic.
Ginsbach JW; Faculty of Science, Charles University, 128 00 Prague 2, Czech Republic.
Andrikopoulos PC; Department of Chemistry, Stanford University, Stanford, CA 94305.
Rulísek L; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 166 10, Prague 6, Czech Republic.
Solomon EI; Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, 166 10, Prague 6, Czech Republic.

Proc Natl Acad Sci U S A ; 119(33): e2205619119, 2022 08 16.

Article en En | MEDLINE | ID: mdl-35939688

Asunto(s)

Proteínas Bacterianas; Melaninas; Monofenol Monooxigenasa; Oxígeno; Fenoles; Streptomyces; Sitios de Unión; Catálisis; Cobre/química; Melaninas/biosíntesis; Monofenol Monooxigenasa/química; Oxígeno/metabolismo; Peróxidos/química; Fenoles/química; Streptomyces/enzimología

Palabras clave

binuclear copper; melanin biosynthesis; monooxygenase; oxygen activation; tyrosinase

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Oxígeno / Fenoles / Streptomyces / Proteínas Bacterianas / Monofenol Monooxigenasa / Melaninas Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article

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