Early life exposures and development of allergic disease in infants with familial risk: Results from ongoing probiotic intervention trials.
Acta Paediatr
; 112(1): 115-121, 2023 01.
Article
en En
| MEDLINE
| ID: mdl-35989564
ABSTRACT
AIM:
We search revision of risk determinants of the ongoing allergy epidemic.METHODS:
Children numbering 433 born to mothers with allergic disease or sensitisation were selected from the three ongoing probiotic intervention trials for this case-control study. Children who developed atopic eczema or food allergy, had positive skinprick test results or had been prescribed inhaled corticosteroids by the age of 2 years were identified as cases (n = 231), while children without allergic manifestations were the healthy controls (n = 202). The data on early environmental exposures were collected from prospectively documented study records. The statistical analyses were adjusted for potential confounders.RESULTS:
Determinants associated with the increased risk of atopic eczema were lower maternal prepregnancy BMI (aOR 0.15, 95% CI 0.037-0.54) and maternal intrapartum antibiotic treatment (aOR 2.21, 95% CI 1.20-4.10), the latter also linked to obstructive respiratory symptoms (aOR 3.87, 95% CI 1.07-14.06). The risk of allergic sensitisation was associated with lower maternal prepegnancy BMI (aOR 0.18, 95% CI 0.43-0.79) and intrapartum antibiotic treatment (aOR 2.13, 95% CI 1.07-4.22).CONCLUSION:
Based on our demonstrations, interventions such as personalised diets, can be optimised for specific subgroups and definite risk periods.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Predisposición Genética a la Enfermedad
/
Hipersensibilidad
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Child
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Child, preschool
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Female
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Humans
Idioma:
En
Revista:
Acta Paediatr
Año:
2023
Tipo del documento:
Article
País de afiliación:
Finlandia