Feasibility study of deep-learning-based bone suppression incorporated with single-energy material decomposition technique in chest X-rays.

ABSTRACT

OBJECTIVE: To improve the detection of lung abnormalities in chest X-rays by accurately suppressing overlapping bone structures in the lung area. According to literature on missed lung cancer in chest X-rays, such structures are a significant cause of chest-related diagnostic errors. METHODS: This study presents a deep-learning-based bone suppression method where a residual U-Net model is trained for chest X-rays using data set generated from the single-energy material decomposition (SEMD) technique on CT. Synthetic projection images and soft-tissue selective images were obtained from the CT data set via the SEMD, which were then used as the input and label data of the U-Net network. The trained network was tested on synthetic chest X-rays and two real chest radiographs. RESULTS: Bone-suppressed images of the real chest radiographs obtained by the proposed method were similar to the results from the American Association of Physicists in Medicine lung CT data; pulmonary nodules in the soft-tissue selective images appeared more clearly than in the synthetic projection images. The peak signal-to-noise ratio and structural similarity values measured between the output and the corresponding label images were approximately 17.85 and 0.90, respectively. CONCLUSION: The proposed method effectively yielded bone-suppressed chest X-ray images, indicating its clinical usefulness, and it can improve the detection of lung abnormalities in chest X-rays. ADVANCES IN KNOWLEDGE The idea of using SEMD to obtain large amounts of paired images for deep-learning-based bone suppression algorithms is novel.