Pearls & Oy-sters: Tumefactive Demyelinating Lesions With MOG Antibodies Preceding Late-Infantile Metachromatic Leukodystrophy.

ABSTRACT

The development of acute neurological dysfunction associated with tumefactive demyelinating lesions (TDL) and mild diffuse involvement of the corpus callosum has been described in children as a sentinel event that may allow diagnosis of juvenile metachromatic leukodystrophy (MLD) at an early and potentially treatable stage. We report a child that developed this clinico-radiological pattern associated with myelin oligodendrocyte glycoprotein (MOG) antibodies several months prior the onset of progressive symptoms of late infantile MLD.